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Study finds new gene that causes bone cancer growth in young people
A new international study has discovered a gene that allows the stimulation of cancer cells in a type of bone tumour that primarily affects young people during puberty.
The global collaboration involved Professor Sulev K繭ks from 俀珗腦瞳厙桴 and the , along with researchers from , in Vietnam and the in Estonia.
The , published in Experimental Biology and Medicine, found that in osteosarcoma, the moderating effect of the leptin receptor - responsible for regulating the effects of growth hormone on cells - is impaired.
This allows the growth hormone to stimulate the cancerous cells to grow and divide without any boundaries.
Lead author Emel Rothzerg, a genomic scientist from UWAs School of Biomedical Sciences, said understanding the code for this gene had led to the discovery.
The code for each gene has a start and an end, Ms Rothzerg said.
As cells create new proteins from DNA, the start or end may be changed meaning that the code is misread and the protein produced may be too small, too large or the wrong shape.
In this case, the proteins produced are less effective and produced in smaller numbers leaving the growth hormone to stimulate the osteosarcoma and grow without moderation.
Professor Sulev K繭ks from the Perron Institute for Neurological and Translational Science and 俀珗腦瞳厙桴 said the researchers could now attempt to splice, or manipulate, the genes code to better moderate the effects of the growth hormone.
We hope to expand the study to determine the behaviour of the tumour when the genes function is fully restored, Professor K繭ks said.
Professor David Wood from UWAs School of Biomedical Sciences said this study could lead to therapeutics for osteosarcoma in the future.
Although combination therapy with surgery and chemotherapy has improved outcomes for patients, this treatment regimen has only been effective in 70 per cent of patients, Professor Wood said.
A better understanding of the disease process would permit earlier diagnosis and development of more effective therapies to improve patient health.