The Personalised Medicine Centre, formerly the Centre for Molecular Medicine and Innovative Therapeutics (CMMIT), is a collaborative research centre between ÍíÒ¹¸£ÀûÍøÕ¾ and the Perron Institute, where cutting-edge laboratory research and clinical expertise converge.
Revolutionising healthcare through Personalised Medicine
Our team of researchers and health professionals, drawn from diverse fields, is united in a shared commitment to advancing personalised medicine - the development of innovative treatments tailored to addressing the specific needs of individual patients, needs that are largely determined by a person’s unique genetic makeup and lifestyle.
We believe personalised medicine has the power to revolutionise healthcare, offering solutions to today’s most pressing diseases in ways that could one day have the same transformative impact as antibiotics had on infectious diseases.
The centre’s core research areas
At the Personalised Medicine Centre, our research spans a broad spectrum of critical healthcare challenges. Our diverse research teams are advancing work in areas such as genetic therapies, genomics, motor neurone disease, sepsis, cognitive health, and neurodegenerative disorders such as Parkinson’s disease, myositis, and multiple sclerosis. We also explore the health benefits of exercise, health economics, mathematical modelling of biological processes, and wound healing.
Since its establishment in 2019, the Centre has made significant strides towards becoming a leading multi-disciplinary research centre, equipped with the depth and breadth of expertise to tackle some of the most pressing issues facing healthcare today. The Centre's ability to adapt and respond to evolving needs is exemplified by the success of its research on COVID-19-related issues, which resulted in new testing techniques and novel therapeutics.
Molecular Therapy
Professor Steve Wilton and Dr May Aung-Htut lead a group that focuses on developing novel therapeutic strategies to treat rare inherited or the much more common acquired human diseases by designing genetic drugs (antisense oligonucleotides.
Professor Rakesh Veedu leads the development of novel therapeutic molecules that facilitate target-specific delivery of drugs or diagnostics to specific disease sites in the body.
Motor Neurone Disease
Professor Anthony Akkari, Dr Loren Flynn and their team are investigating new approaches to the treatment of the fatal motor neurone disease (MND), a disease affecting 350,000 people worldwide.
Professor Sulev Kõks and his team aim to probe the genetics and molecular pathology of Parkinson’s Disease – with the goal of improving the precision clinical management of patients.
Myositis
Professor Merrilee Needham and her team are investigating the treatment, genetics and immuno-pathology of immune-mediated myositis, particularly inclusion body myositis.
Oligo Therapeutics
Following the global breakthrough she and Professor Steve Wilton pioneered, developing compounds to treat Duchenne muscular dystrophy as well as a range of other rare disorders, Emeritus Professor Fletcher, Dr Ianthe Pitout and their team research into inherited blindness and neurodegenerative diseases.
Sepsis Diagnostic Research
Dr Andrew Currie leads a collaborative team of clinicians, veterinarians and medical researchers invested in finding new and better ways to diagnose, treat and prevent sepsis in newborns, adults and companion animals.
Functional Genomics
Dr Sarah Rea investigates the functional consequences of genetic changes that are associated with neurodegenerative diseases such as ALS and Dementia and aims to identify novel therapeutic strategies to combat these diseases.
Drug Hypersensitivity
Dr Andrew Gibson and Professor Elizabeth Phillips lead immunogenomics research to identify genetic-, cellular-, and structural-risk factors that will predict and prevent life-threatening immune-mediated drug reactions.
Medical Genomics
Professor Sulev Koks' team in the centres accredited, high throughput medical genomics facility supports medical and one health researchers locally and across the globe from research concept to market.
Skin Integrity
Skin Integrity Research Group led by Associate Professor Kylie Sandy-Hodgetts research focuses on the clinical prevention and early identification of surgical wound complications such as surgical site infection and surgical wound dehiscence. The programme includes Phase 1-IV clinical trials, comparative effectiveness studies, validation of diagnostic methods for identification and classification of wound infection, and the development of AI tools to predict at risk patient groups.
Clinical Exercise and Cognition
This interdisciplinary team brings expertise in biomechanics, physiology, motor control and cognition to support the development of precision exercise and rehabilitation therapies.
Economic Evaluation of Disease & Diagnostics
Associate Professor Khurshid Alam leads a group in the field of health economics and health care financing research in Murdoch where they conduct cost-effectiveness and cost-benefit analysis to examine value for money (VfM) and resource-allocation for clinical, laboratory and public health interventions.
Demyelinating Diseases Group (including Multiple Sclerosis)
Clinical Professor Allan Kermode and his team explore the clinical, laboratory, radiological, and immunogentic aspects of multiple sclerosis and related disorders, which affect over 25,000 Australians.
Cell-Tissue Systems Modelling
Professor Bruce Gardiner’s research uses computational and mathematical models to integrate the physical, chemical and biological processes underlying diseases such as osteoarthritis, colorectal cancer, acute kidney injury and glaucoma.
Professor Anthony Akkari the Director of the Personalised Medicine Centre. He is a pharmacogeneticist and neuromuscular geneticist with 28 years research experience in Australia and the US. He leads his dually based research group at CMMIT and the Perron Institute in developing new strategic approaches to identifying genetic mechanisms and mutations in neurological diseases, with the aim of developing new and personalised treatments for motor neurone disease.
Professor Steve Wilton AO is a world-renowned researcher who together with Professor Sue Fletcher has made global breakthroughs in the treatment of Duchenne muscular dystrophy (DMD). Professor Wilton’s research focuses on an increasing array of diseases, including spinal muscular atrophy, Pompe’s disease, motor neurone disease and multiple sclerosis. Over 50 different diseases are currently being studied. Steve Wilton is Director of the Perron Institute and Deputy Director of the Personalised Medicine Centre.
Dr May Aung-Htut is a Senior Research Fellow and Co-Head of the Molecular Therapy Group with Professor Steve Wilton. She is an experienced and dedicated scientist with a proven record of accomplishment in molecular and cell biology. Dr Aung-Htut is the leader of Discovery and Research in the Sarepta Translational Laboratory, developing and refining antisense oligomers targeting inherited and acquired conditions including other muscular dystrophies, multiple sclerosis, Alzheimer’s, Pompe’s disease, asthma and neuroinflammatory conditions.
Professor Veedu has dual appointment as head of Nucleic Acid Therapeutics Research within the Personalised Medicine Centre and the Perron Institute. Rakesh received his PhD from the University of Queensland after completing his MSc degree from Griffith University. He has over 14 years’ experience in basic and translational research in the field of oligonucleotide therapeutic development, and published >90 articles in reputed journals.
Joining the Personalised Medicine Centre and the Perron Institute from Estonia in 2018, Professor Kõks’ research focuses on understanding the molecular mechanisms underlying neurodegenerative disorders, including Parkinson’s disease. He also researches into, and has vast experience in psoriasis, psoriatic arthritis, osteoporosis and osteosarcoma. Professor Kõks is a highly published researcher and is an active member of several international research consortia.
Emeritus Professor Fletcher AO is a molecular biologist and Senior Principal Research Fellow who has been integral in pioneering therapeutic antisense oligomer development in partnership with Professor Steve Wilton. Together they created the first two FDA approved therapeutic treatments for Duchenne muscular dystrophy. Professor Fletcher’s research interest area has expanded into inherited blindness and neurodegenerative disease. She is a passionate and involved patient and community advocate, as well as a dedicated volunteer for support organisations.
Professor Needham is a Consultant Neurologist seeing neuromuscular and myositis patients at Fiona Stanley Hospital, the Perron Institute and IIID at ÍíÒ¹¸£ÀûÍøÕ¾. Professor Needham also leads the dually based Myositis Research Group at the Personalised Medicine Centre and the Perron Institute. She is passionate and well versed in all things Inclusion Body Myositis, having a fantastic rapport with her patients and colleagues.
Dr Loren Flynn is a molecular geneticist and mid-career researcher with a research focus on the development of antisense oligonucleotides (AOs) and their application in translational medicine. Experience in the evaluation of AOs in both in vitro and in vivo models, as well as experience working with industry in drug development and FDA regulatory procedures for a rapid pre-clinical translation of AO therapies. Alongside Professor Anthony Akkari, they lead the dually based Motor Neurone Diseases Genetics and Therapeutics group at Murdoch’s Personalised Medicine Centre and the Perron Institute.
Dr Ianthe Pitout is a molecular geneticist at ÍíÒ¹¸£ÀûÍøÕ¾ focused on RNA-targeted therapeutics to treat degenerative diseases. An early career researcher with 10 years of experience in the design and evaluation of splice switching antisense oligonucleotides for translational applications, she is an experienced biotechnology researcher, having worked in both academic and industry sectors. She currently leads the Oligo Therapeutics laboratory where her team are developing AO therapeutics for motor neuron disease, inherited blindness and other neurodegenerative conditions.
A/Prof and drug hypersensitivity research lead at the Personalised Medicine Centre, ÍíÒ¹¸£ÀûÍøÕ¾ using immunogenomics to understand the immunogenic potential of new and existing drugs. I have been successful in attracting both state and nationally competitive (NHMRC) funding. I am also currently the chair of the Murdoch EMCR advisory group, deputy state rep for the Australasian Society of Diagnostic Genomics (ASDG), and a member of both the Murdoch PMC senior leadership team and ASCEPT and RCPA national working groups for pharmacogenomics implementation.
Professor Currie co-heads the Neonatal Infection and Immunity Team with Neonatologist Clinical Prof Tobias Strunk at the Wesfarmers Centre of Vaccine & Infectious Diseases, Telethon Kids Institute and leads the Sepsis Diagnostics Research Group with the Personalised Medicine Centre. As a basic scientist with over 20 years of experience in the fields of immunology and infectious disease, his current research combines current cellular and molecular ‘omics’ methodologies with primary human and animal samples, to understand how the immune system contributes to defence against infection in sepsis.
Dr Rea is a Senior Research Fellow and mid-career researcher with 10 years postdoctoral experience. Her research is focused on understanding the mechanisms underlying dementia and neurodegeneration. Dr Rea uses innovative analytical techniques to demonstrate changes to key biochemical, cellular and structural components of neurons in response to genetic risk factors.
Professor Gardiner has 25 years of computational modelling experience. His expertise is modelling cell-tissue interactions and inter- and intra-cellular communication networks. This requires multidisciplinary expertise beyond biomedical science, and includes material science, mechanics and transport processes (from chemical and mechanical engineering), control systems and applied mathematics.
Mark is a molecular biologist with a longstanding research interest in virology, with a focus on molecular biology and immunology and antivirals with more recent interest being in cancer immunology. His team works with researchers to achieve their research goals specialising in immunology and infectious disease. He also plays a key role in the health research building ensuring that things run smoothly.
Clinical Professor Kermode is a Consultant Neurologist and Head of the Demyelinating Diseases Research the Personalised Medicine Centre and the Perron Institute. Highly awarded and published, Allan’s broad training incorporates not only clinical neurology, clinical immunology, electrophysiology and neuroradiology, but also several years of virology, cellular immunology and molecular biology bench work.
Dr Chopra leads research and development for Murdoch’s Medical Genomics Research Facility and has established a world class, state of the art accredited laboratory specializing in molecular genomics. She has an extensive track record in driving the development of novel, leading-edge techniques and analysis tools utilized by academic and industry collaborators throughout the world.
Associate Professor Kylie Sandy-Hodgetts is a Senior Research Fellow leading the Skin Integrity research group at the Personalised Medicine Centre. Her research interests are in wound healing, prevention, risk assessment and clinical trials in surgical wound healing and is Chief Investigator of a number of clinical trials Phase I - IV. Kylie is the Founder and inaugural President of the International Surgical Wound Complications Advisory Panel (ISWCAP), a culmination of her research activity and doctoral work into early identification and prevention of surgical wound complications.
Khurshid Alam is an Associate Professor in Health Economics at the Murdoch Business School. A/Professor Alam did his PhD in Health Economics from Monash University in 2015. His primary expertise is in cost-effectiveness and cost-benefit analysis to examine value for money (VfM) and resource-allocation for clinical and public health interventions and diagnostic trajectories of rare diseases. His research interests extend to health care financing, health systems, health services, health policy, health equity and global health where he supervises multiple PhD students as a primary supervisor.
To learn more about the centres' research, view our Annual Reports.
Please note that our Centre’s name has changed to Personalised Medicine Centre in 2025 and was previously the Centre for Molecular Medicine and Innovative Therapeutics, brochures are currently being updated.
Commercial services
The Personalised Medicine Centre offers a world-class service in the design and pre-clinical testing of antisense oligonucleotide and other nucleic acid-based therapeutics for industry and academia. To learn more about our services, contact pmc@murdoch.edu.au or see the brochure below:
Postgraduate study research opportunities
You can apply for a research degree at the Personalised Medicine Centre at any time during the year. To learn more about our research areas, supervisors, and project opportunities, contact pmc@murdoch.edu.au or see the brochure below: